Bruno Rizzuti Selected Research

Inosine Diphosphate (IDP)

10/2021	Design of Inhibitors of the Intrinsically Disordered Protein NUPR1: Balance between Drug Affinity and Target Function.
2/2021	Intrinsically disordered protein NUPR1 binds to the armadillo-repeat domain of Plakophilin 1.
11/2019	Targeting the Stress-Induced Protein NUPR1 to Treat Pancreatic Adenocarcinoma.
11/2019	Dynamics of the intrinsically disordered protein NUPR1 in isolation and in its fuzzy complexes with DNA and prothymosin α.
1/2019	Ligand-based design identifies a potent NUPR1 inhibitor exerting anticancer activity via necroptosis.
1/2018	The chromatin nuclear protein NUPR1L is intrinsically disordered and binds to the same proteins as its paralogue.
1/2018	Amphipathic helical peptides hamper protein-protein interactions of the intrinsically disordered chromatin nuclear protein 1 (NUPR1).
8/2017	Intrinsically disordered chromatin protein NUPR1 binds to the C-terminal region of Polycomb RING1B.
1/2017	Identification of a Drug Targeting an Intrinsically Disordered Protein Involved in Pancreatic Adenocarcinoma.
1/2016	Determinants of the pKa values of ionizable residues in an intrinsically disordered protein.

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Bruno Rizzuti Research Topics

Disease

12	Neoplasms (Cancer) 01/2022 - 04/2018
4	Adenocarcinoma 11/2019 - 01/2017
3	Breast Neoplasms (Breast Cancer) 12/2022 - 01/2019
3	Infections 09/2021 - 04/2021
3	COVID-19 06/2021 - 12/2020
3	Pancreatitis 11/2019 - 01/2018
3	Pancreatic Neoplasms (Pancreatic Cancer) 01/2019 - 01/2016
1	Hypercholesterolemia 09/2021
1	Sepsis (Septicemia) 05/2021
1	Inflammation (Inflammations) 05/2021
1	Hypertrophy 01/2021
1	Hypertrophic Cardiomyopathy (Hypertrophic Obstructive Cardiomyopathy) 01/2021
1	Venous Thrombosis (Deep-Vein Thrombosis) 11/2019
1	Pulmonary Embolism 11/2019
1	Inborn Genetic Diseases (Disease, Hereditary) 03/2019
1	HIV Infections (HIV Infection) 02/2019
1	Triple Negative Breast Neoplasms 01/2019
1	Neoplasm Metastasis (Metastasis) 01/2019
1	Prostatic Neoplasms (Prostate Cancer) 04/2018
1	Carcinogenesis 08/2017
1	Mitochondrial Diseases (Mitochondrial Disease) 11/2016

Drug/Important Bio-Agent (IBA)

12	Proteins (Proteins, Gene)FDA Link 01/2022 - 01/2016
10	Inosine Diphosphate (IDP)IBA 10/2021 - 01/2016
10	Intrinsically Disordered ProteinsIBA 10/2021 - 01/2017
5	Pharmaceutical PreparationsIBA 10/2021 - 01/2016
3	Antiviral Agents (Antivirals)IBA 09/2021 - 04/2021
3	Peptides (Polypeptides)IBA 05/2021 - 01/2019
3	NUPR1 inhibitor ZZW-115IBA 01/2020 - 01/2019
2	Flavin-Adenine Dinucleotide (FAD)IBA 01/2022 - 03/2019
2	Biological ProductsIBA 10/2021 - 01/2019
2	Hormones (Hormone)IBA 01/2020 - 04/2018
2	GTP-Binding Proteins (G-Protein)IBA 01/2020 - 01/2019
1	Letrozole (Femara)FDA LinkGeneric 12/2022
1	Aromatase (CYP19)IBA 12/2022
1	quinone (benzoquinone)IBA 01/2022
1	Oxidoreductases (Dehydrogenase)IBA 01/2022
1	NADP (NADPH)IBA 01/2022
1	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 09/2021
1	Peptide Hydrolases (Proteases)FDA Link 09/2021
1	Messenger RNA (mRNA)IBA 05/2021
1	Chromogranin AIBA 05/2021
1	Toll-Like Receptor 4IBA 05/2021
1	p38 Mitogen-Activated Protein KinasesIBA 05/2021
1	chromogranin A (344-358)IBA 05/2021
1	LipopolysaccharidesIBA 05/2021
1	Interleukin-6 (Interleukin 6)IBA 05/2021
1	Isoproterenol (Isoprenaline)FDA LinkGeneric 01/2021
1	Brain Natriuretic Peptide (Natrecor)FDA Link 01/2021
1	TropomyosinIBA 01/2021
1	QuercetinIBA 12/2020
1	Nuclear Proteins (Protein, Nuclear)IBA 01/2020
1	Estrogens (Estrogen)FDA Link 01/2020
1	Heat-Shock Proteins (Heat-Shock Protein)IBA 01/2020
1	Estrogen Receptor alphaIBA 01/2020
1	Human Serum Albumin FDA LinkGeneric 11/2019
1	AnticoagulantsIBA 11/2019
1	Warfarin (Coumadin)FDA LinkGeneric 11/2019
1	MethylcholanthreneIBA 08/2019
1	FlavoproteinsIBA 03/2019
1	ProteomeIBA 03/2019
1	EnzymesIBA 03/2019
1	Furylfuramide (AF2)IBA 01/2019
1	Trifluoperazine (Stelazine)FDA LinkGeneric 01/2019
1	Estrogen ReceptorsIBA 01/2019
1	Antipsychotic Agents (Antipsychotics)IBA 01/2019
1	IsoflavonesIBA 04/2018
1	GenisteinIBA 04/2018
1	ChromatinIBA 01/2018

Therapy/Procedure

1	Therapeutics 02/2019